ABSTRACT
Objective:To investigate the distribution of traditional Chinese medicine (TCM) syndromes in patients with coronary heart disease (CHD) in 6 months after interventional therapy, and to analyze relevant influencing factors. Method:The clinical data of 1 000 patients with coronary heart disease in 6 months after interventional therapy, including the four diagnosis information of TCM, were collected, and the distribution of TCM syndromes and the influencing factors were analyzed. Result:Among 48 kinds of information about the four diagnostic methods of TCM, chest pain was the most frequent (98.10%)， among 9 kinds of common TCM syndrome types, blood stasis was the most frequent (89.90%), and the others were heart-Qi deficiency syndrome, phlegm turbidity syndrome, cold-dampness syndrome, kidney-Qi deficiency syndrome, heart-Yin deficiency syndrome, kidney-Yin deficiency syndrome, Heart-Yang deficiency syndrome and kidney-Yang deficiency syndrome in turn. Among 6 common TCM syndrome types, Qi deficiency and blood stasis syndrome were the most frequent (35.40%), and the others were phlegm turbidity and blood stasis syndrome, cold congealing heart pulse syndrome, Qi-Yin deficiency syndrome, heart-kidney Yin deficiency syndrome and heart-kidney-Yang deficiency syndrome in turn. There was no significant difference in sex ratio among different syndrome types . Patients with heart-kidney Yang deficiency syndrome had no significant difference. Compared with the average age of other syndromes, there were significant differences. Common complications included hypertension, diabetes, cerebrovascular diseases and dyslipidemia, among which hypertension had the highest frequency, with significant differences from other diseases (P<0.05). Phlegm, turbidity and blood stasis were found in patients with hypertension. The risk of syndromes was higher (OR=3.29, 95% CI [2.11, 5.05]), while the risk of cold congealing heart pulse syndrome was lower (OR=0.56, 95% CI [0.32, 0.98]), the risk of Qi and Yin deficiency was higher (OR=2.88, 95% CI [2.01, 4.99]), whereas the risk of heart and kidney Yang deficiency was lower (OR=0.54, 95% CI [0.29, 0.95]) when complicated with cerebrovascular diseases. The risk of Qi deficiency and blood stasis was higher (OR=2.97, 95% CI [2.05, 5.28]), while the risk of heart and kidney Yang deficiency was lower (OR=0.54, 95% CI [0.29, 0.95])， the risk of phlegm turbidity and blood stasis was higher when complicated with dyslipidemia (OR=3.55, 95% CI [2.32, 5.29]), and the risk of heart and kidney Yang deficiency was lower (OR=0.54, 95% CI [0.29, 0.95]). The time distribution of the disease had obvious seasonal characteristics. Conclusion:The main distribution characteristics of TCM syndromes in 6 months after coronary heart disease intervention are basically the same as those in patients without intervention. The main TCM syndromes are Qi deficiency and blood stasis syndrome, phlegm turbidity and blood stasis syndrome, cold congealing heart pulse syndrome, Qi-Yin deficiency syndrome, heart-kidney Yin deficiency syndrome and heart-kidney-Yang deficiency syndrome. The distribution pattern may be related to age, complications and seasons.
ABSTRACT
With the advance of aging in the world, aging and its relevant cardiovascular diseases have become an important concern for medical care. Aging is a universal and multifactorial process characterized by a gradual decline in physiological functions, cell dysfunction and a variety of diseases. Telomere shortening is currently a hallmark of vascular aging. The shortening of telomere length is accelerated by exposure to smoking, obesity and other factors. Telomere shortening and dysfunction play crucial roles in the pathogenesis of senile-related cardiovascular diseases. Cardiovascular risk factors, such as smoking, high blood pressure, diabetes, obesity and stress are considered to increase oxidative stress or inflammation, accelerate the shortening of telomeres, and protect the healthy telomere length. Previous studies have also shown that telomere shortening is closely related to atherosclerotic cardiovascular disease. This may be an effective biomarker for the risk stratification of cardiovascular disease. According to the theory of traditional Chinese medicine(TCM), human aging and kidney deficiency are accompanied. The heart and kidney are interrelated and mutually constrained for coordinating water and fire. Impaired heart function due to kidney deficiency and self-aging can cause relevant cardiovascular diseases. The study found that TCM or prescriptions for activating blood circulation to remove blood stasis and many kidney-reinforcing TCM or prescriptions are likely to affect cardiovascular diseases by altering telomere length and telomerase activity. In today' s aging society, TCM for promoting blood circulation, removing blood stasis and tonifying kidney from the perspective of telomere is of great significance for the pathological mechanism of cardiovascular diseases.